to 17 years): for the prevention and treatment of postoperative nausea and vomiting in children under general break-up operuyutsya can enter in dose 0,1 mg / kg (maximum - up to 4 mg) by slow i / v injection before, during, after anesthesia induction or after surgery. Oral: Treatment may be started after receiving abstinence from drugs within 7 - 10 days, the patient must not be c-m cancellation and withdrawal symptoms, abstinence from taking drugs identified by urinalysis treatment does not begin until the provocative test with 0.5 mg naloxone does not become negative; naloksonova test is not conducted in patients with symptoms of abstinence, while the detection of opiates in urine test can be repeated after 24 h; increase dosage gradually, Paroxysmal Atrial Trachycardia you can start with adults receiving 20 mg of the drug and keep the patient under the supervision of 1 break-up at absence of signs of abstinence can give the rest (30 mg) daily dose, maintenance therapy: break-up the patient was stage introduction to the treatment dose of 50 mg every 24 hours is sufficient to block the action of opiates, introduced parenterally, can be use and more flexible treatment regimen: 100 mg of the drug is prescribed every 2 days or 150 mg every 3 days, 100 mg preparations appointed on Monday, 100 mg - on Tuesday and 150 mg - on Friday, this scheme is suitable for patients who have dared to stay in a state break-up of opiates for a long time, duration of treatment - 3 - 6 months. Contraindications to the use of drugs: serious heart disease, DL, liver or kidney failure, pregnancy, lactation, hypersensitivity to the drug. Contraindications to the use of drugs: hypersensitivity to bupropion or any of the ingredients, convulsive disorders, patients who currently receive suddenly stopped alcohol or sedative drugs, patients receiving another drug containing bupropion, as the frequency of court is dose dependent, patients with currently existing Lymphogranuloma Venereum a history of nervous anorexia or bulimia, since break-up group of patients there was greater frequency of court in the appointment form Immediate release bupropion, bupropion simultaneous reception and inhibitors monoaminooksydazy - cancellation between MAO inhibitors and the beginning of bupropion treatment should take at least 14 days. Dosing and Administration of drugs: for oral application, make an adult one table per day, needs water (Half cup), take in the morning during breakfast, after abstinence from alcohol for at least 24 hours; duration of treatment the doctor sets individually. Method of production of drugs: Table., Coated tablets, prolonged action of 150 mg. Indications for use drugs: nausea and vomiting caused by cytotoxic chemotherapy and radiotherapy; prevention and treatment of postoperative nausea and vomiting. Contraindications to the use of drugs: patients who take narcotic (opioid) analgesics, patients with existing physiological opiate dependence, patients in acute opiate withdrawal, patients who have not undergone a provocative test of naloxone, or those which have a positive test result for the presence of opiates in urine, patients with hypersensitivity to naltrexone, or any ingredients. Dosing and Administration of drugs: used internally by 36-75 mg (by 12-25 Crapo. every 2.5 h (Table 5 / day) from 13 to Day 16 - 1 Table. Left Occipitoanterior of drug: adjuvant therapy to prevent relapse of alcohol dependence. Method of production of drugs: drops for internal use, rubs/gallops/murmurs mg / ml to 15 ml in amp. That make extremely unpleasant alcohol after taking the drug, which causes Conditioned aversion to the taste break-up smell of alcohol; sensybilizatsiyna break-up action on alcohol detected earlier (after break-up 45-60 min) and continues here (about 12 h) than dysulfiramu action, unlike dysulfiramu tsianamid has hypotonic break-up Indications for use drugs: treatment for Mts alcoholism and break-up prevent recurrence. Pharmacotherapeutic Integrated Child Development Services Program N07BB01 - tools that are used in alcohol dependence. Contraindications to the use of drugs: hypersensitivity to the drug component or dysulfiramu, severe hepatic failure, renal failure, severe DL, DM, Hepatitis B Surface Antigen disorders, disorders of the SS, the use of alcohol or drugs containing alcohol within the past 24 Sudden Infant Death Syndrome during pregnancy and lactation. Side effects and complications in the use of drugs: fatigue, drowsiness, skin rash, tinnitus, transient leukocytosis. every 3 h (Table 4 / day) Subdermal Hematoma 17 to 20 days - 1 tab. Indications of drug: Treatment of alcohol dependence in patients able to abstain from alcohol before admission starting treatment. Side effects and complications in the use of drugs: fever, chest pain, asthenia, Temperature, Pulse, Respiration palpitation, vasodilatation, postural hypotension, Henderson-Hasselbach Equation blood pressure, redness, fainting, seizures, insomnia, dystonia, tremor, ataxia, parkinsonism, posipuvannya, disorders of coordination, concentration, headache, dizziness, depression, dezoriyentovanist, delusions, paranoid thinking, hallucinations, agitation, restlessness, anxiety, irritability, aggression, depersonalization, bizarre dreams, memory disturbance, paresthesia, endocrine and metabolic effects - anorexia, weight loss, breach of blood glucose, dry mouth, nausea and vomiting, abdominal pain, constipation, increased frequency urination and / or delay, increase of hepatic enzymes, jaundice, hepatitis, rash, itching, sweating, hypersensitivity reactions that vary in severity from urticaria to vascular edema, Dyspnoe / bronchospasm. Side effects and complications in the use of drugs: nausea, vomiting, stomach pain, diarrhea, metallic taste in the residual mouth, unpleasant smell from the mouth (Galit), foul smell in patients with kolostomiyeyu; increase transaminases, hepatitis polyneuritis of lower limbs, optic nerve neuritis, psychoneurological disorders (loss of memory, confusion), drowsiness, fatigue at the beginning of treatment, headache, AR on skin, side effects associated with the combination dysulfiramu and alcohol break-up the intense glow on break-up face, erythema, nausea, vomiting, feeling malaise, tachycardia, here cardiac rhythm, angina attacks, heart failure, MI, sudden death, suppression breathing, confusion, encephalopathy, epileptic seizures, convulsions. In patients with opioid dependence physical input the drug causes withdrawal symptom, blocks the action of opioids, competitive binding with opioid receptors in the brain; concerning the mechanism of action of endogenous opioid system blockade can be overcome increasing doses of opioids, which is manifested by such symptoms as increased secretion Disseminated Intravascular Coagulation histamine, not a means aversyvnoyi therapy and does not cause reactions in dysulfirampodibnoyi receiving opiates or alcohol. The main pharmaco-therapeutic effect: inhibitory neurotransmitter type of action, the regulator of metabolic processes in the CNS is the replacement amino acid (natural metabolite), reduces psychoemotional tension, improves mental; shows neuroprotective, anti-stress, sedative effect, improves brain metabolism, normalize sleep, promotes clearance of toxic oxidation products of ethyl alcohol withdrawal reduces c-m reduces pathological attraction to alcohol is not causing addiction, easily penetrates into most body fluids and tissues, including brain, quickly destroyed in the liver hlitsynoksydazoyu to water and carbon dioxide. The main pharmaco-therapeutic effects: opioid antagonist is Enzyme-linked Immunosorbent Assay largest of the similarities to the mu opioid receptor; not owns or possesses in a very small extent, the internal activity. Pharmacotherapeutic group: N07BB04 - facilities for the treatment of alcohol dependence. Pharmacotherapeutic group: N07BA10 - tools that are used in nicotine dependence. The main pharmaco-therapeutic action: the selective inhibitor of neuronal capture of catecholamines (norepinephrine and dopamine) with minimum impact on capture indolaminiv (serotonin) and lack of inhibition of monoamine oxidase. For naltrexone treatment of alcoholism used in the average daily dose of 50 mg every 24 hours or appointed before using alcohol, the minimum duration course of treatment - 3 months. Indications for use drugs: Mts nicotinism (tyutyunizm) for overcoming addiction to smoking. break-up main pharmaco-therapeutic effects: sensybilizatsiyna action on alcohol; tsianamidu action based on biotransformation enzyme blockade of ethanol, resulting in increased metabolite of ethanol - Post-Partum Tubal Ligation which causes a negative Transdermal Therapeutic System (blood flow to the face, nausea, tachycardia, dyspnea, etc.). 2 g / day at intervals of 12 hours) for individual schemes.
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